Cell Factory Policlinico

Published:

M. Corselli, CW Chen, N. Crisan, L. Lazzari, B. Péault. Perivascular ancestors of adult multipotent stem cells. Arterioscler Thromb Vasc Biol , 2010 Jun; 30 (6): 1104-9. Epub 2010, May 7th

P. Rebulla, T. Montemurro, R. Giordano. Regulation of cell-based medicine: the European exprience. ISBT Science Series (2010) 5, 249-251

Capra E, Beretta R, Parazzi V, Lazzari L, Baldi A, Giordano R. GMP-produced ADMSC from different donors show similar proteomic changes in time, low telomerase activity and a stable phenotype in culture. Cascade Governing Board Meeting. 12-13 January 2010

Montelatici E. Viganò M, Chelli F, Parazzi V, Spaltro G, Giordano R, Lazzari L. Molecular and secretory profiles of human mesenchymal stem cells from adipose tissues and their ability to maintain primitive hematopoietic progenitors. Stem Cell Differentiation and Dedifferentiation meeting, February 2010, Keystone, CO, USA

Montelatici E, Montemurro T, Parazzi V, Andriolo G, Vigano' M, Chelli F, Spaltro G, Lovati A, Giordano R, Lazzari L. Human cord blood mesenchymal stem cells for regenerative medicine: isolation, characterization, secretory profile and aging. 4rd UK Mesenchymal Stem Cell Meeting April 2009, Leeds, UK

Montinaro M, Zanier ER, Viganò M, Villa P, Fumagalli P, Pischiutta F, Longhi L, Leoni ML, Rebulla P, Stocchetti N, Lazzari L, De Simoni MG. Effects of cord blood mesenchymal stem cell infusion after focal ischemia or traumatic brain injury. The First Symposium on Stem Cell Research for Stroke, Lille, France, May 2010

Montinaro M, Zanier ER, Viganò M, Villa P, Fumagalli S, Pischiutta F, Leoni ML, Rebulla P, Stocchetti N, Lazzari L, De Simoni MG. Effects of human cord blood mesenchymal stem cells in mouse models of acute brain injury. The 7th meeting of the Scottish Neuroscience Group, Glasgow, United Kingdom, August 2010

Andriolo G, Montelatici E, Viganò M, Spaltro G, Giovannelli S, Lecchi L, Lazzari L. Validation of new cord blood preservation bag. ISCT Europe meeting, September 2010, Belgirate (Italy)

Spaltro G, Paccapelo C, Andriolo G, Mantovani R, Rebulla P, Marconi M, Lazzari L, Villa MA. Megakaryocyte expansion and platelet production from cord blood using an optimized GMP two-step culture system. AABB Meeting, October 2010, New Orleans, LA (USA)

Lazzari L. Hematopietic and non-hematopoietic applications of cord blood stem cells. Symposium on Regenerative Medicine - The European Tendencies, Belgrad, Serbia -October 2010

Spaltro G, Paccapelo C, Andriolo G, Rebulla P, Marconi M, Villa MA, Lazzari L. Cord blood megakaryocyte expansion using an optimized GMP two-step culture system. November 2010, Marseille (France)

Spaltro G, Vigano' M, Chelli F, Parazzi V, Montelatici E, Andriolo G, Montemurro T, Giordano R, Lazzari L. Human cord blood mesenchymal stem cells for regenerative medicine. 5° Convegno Internazionale sulle cellule staminali, Agrigento, Italy, Novembre 2010

Vigano M, Spaltro G, Parazzi V, Lavazza C, Montelatici E, Andriolo G, Montemurro T, Lazzari L, Giordano R. Human cord blood mesenchymal stem cells for regenerative medicine, First European Conference on Mesenchymal Stem Cells, Tolouse, France, November 2010.

Montelatici E, Montemurro T, Andriolo G, Chelli F, Viganò N, Parazzi V, Spaltro G, Lazzari R, Rebulla P, Giordano R. Hematopoietic cell preparation for non haematopoietic purposes: methods and results of GMP validation. ASH Meeting, December 2010, Orlando, FL (USA)

Montemurro T, Parazzi V, Spaltro G, Montelatici E, Chelli F, Viganò M, Andriolo G, Giordano R, Rebulla P, Lazzari L. High potential cord blood mesenchymal stem cells with angiogenic properties for endothelial re generation. ASH Meeting, December 2010, Orlando, FL (USA)

Morigi M, Rota C, Montemurro T, Montelatici E, Lo Cicero V, Imberti B, Abbate M, Zoja C, Cassis P, Rebulla P, Benigni A, Remuzzi G, Lazzari L. Life-sparing effect of human cord-blood mesenchymal stem cells in experimental acute kidney injury. Stem Cells, 28:513-22, 2010

Carrassa L, Montelatici E, Lazzari L, Zangrossi S, Simone M, Broggini M, Damia G. Role of Chk1 in the differentiation program of hematopoietic stem cells. Cellular and Molecular Life Sciences, 67:1713-22, 2010

Montemurro T, Andriolo G, Montelatici E, Weissmann G, Crisan M, Colnaghi MR, Rebulla P, Mosca F, Péault B, Lazzari L. Differentiation and migration properties of human fetal umbilical cord perivascular cells: potential for lung repair. Journal of Cellular and Molecular Medicine, 2010 Febr 22. [Epub ahead of print]

Corselli M, Chen CW, Crisan M, Lazzari L, Péault B. Stem cell storage in blood vessel walls. Arteriosclerosis, Thrombosis and Vascular Biology.

Tipping AJ, Pina C, Castor A, Hong D, Rodrigues NP, Lazzari L, May GE, Jacobsen SE, Enver T. High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle. Blood. 113:2661-72, 2009

Brevini TA, Pennarossa G, Antonini S, Paffoni A, Tettamanti G, Montemurro T, Radaelli E, Lazzari L, Rebulla P, Scanziani E, de Eguileor M, Benvenisty N, Ragni G, Gandolfi F. Cell Lines Derived from Human Parthenogenetic Embryos Can Display Aberrant Centriole Distribution and Altered Expression Levels of Mitotic Spindle Check-point Transcripts. Stem Cell Rev Rep. 2009 Sep 9. [Epub ahead of print]

Crisan M, Chen CW, Corselli M, Andriolo G, Lazzari L, Péault B. Perivascular multipotent progenitor cells in human organs. Ann N Y Acad Sci. 1176:118-23, 2009

Sensebè L, Krampera M, Schrezenmeier H, Bourin P, Giordano R. Mesenchymal stem cells for clinical application. Vox Sanguis 2009

Rebulla P, Lecchi L, Lazzari L, Giordano R, Porretti L, Giovanelli S, Salvaterra E, Clerici L, Baldocchi G. Development of a biological resource center for cellular therapy and biobanking in a public polyclinic university hospital. Biologicals. 36:79-87, 2008

Lo Cicero V, Montelatici E, Cantarella G, Mazzola RF, Sambataro G, Rebulla P, Lazzari L. Do mesenchymal stem cells play a role in vocal fold graft survival? Cell proliferation. 41: 460-473, 2008

Crisan M, Deasy B, Gavina M, Zheng B, Huard J, Lazzari L, Peault B. Purification and long-term culture of multipotentn progenitor cells affiliated with the walls of human blood vessels: myoendothelial cells and pericytes. Methods Cell Biol. 86: 295-309, 2008

Ciulla MM, Montelatici E, Ferrero S, Braidotti P, Paliotti R, Annoni G, De Camilli E, Busca G, Chiappa L, Rebulla P, Magrini F, Lazzari L. Potential advantages of cell administration on the inflammatory response compared to standard ACE inhibitor treatment in experimental myocardial infarction. J Transl Med. 12: 6-30, 2008

Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J, Péault B. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell. 3:301-13, 2008

Montemurro T, Bossolasco P, Cova L, Zangrossi S, Calzarossa C, Buiatiotis S, Soligo D, Silani V, Lambertenghi Deliliers G, Rebulla P, Lazzari L. Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential. Biomed Mater Eng. 18:183-5, 2008

Ciulla MM, Ferrero S, Montelatici E, Gianelli U, Braidotti P, Calderoni S, Paliotti R, Annoni G, De Camilli E, Busca G, Magrini F, Bosaria S, Lazzari L, Rebulla P. Assessment of selective homing and contribution to vessel formation of cryopreserved peripherally injected bone marrow mononuclear cells following experimental myocardial damage. Cardiovascular and Hematological Disorders-Drug Targets 6:141-9.

Zangrossi S, Marabese M, Broggini M, Giordano R, D'Erasmo M, Montelatici E, Intini D, Neri A, Pesce M, Rebulla P, Lazzari L. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells. 25:1675-80, 2007

Ciulla MM, Giorgetti A, Giordano R, Silvestris L, Cortina M, Paliotti R, Lazzari L. Circulating endothelial progenitor cell colony-forming capacity in healthy subjects: how does an endothelial colony look like? Am J Cardiol 100: 559-560, 2007

Zangrossi S, Marabese M, Broggini M, Giordano R, D'Erasmo M, Montelatici E, Intini D, Neri A, Pesce M, Rebulla P, Lazzari L. Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells. 25:1675-80, 2007

Torrente Y, Belicchi M, Marchesi C, Dantona G, Cogiamanian F, Pisati F, Gavina M, Giordano R, Tonlorenzi R, Fagiolari G, Lamperti C, Porretti L, Lopa R, Sampaolesi M, Vicentini L, Grimoldi N, Tiberio F, Songa V, Baratta P, Prelle A, Forzenigo L, Guglieri M, Pansarasa O, Rinaldi C, Mouly V, Butler-Browne GS, Comi GP, Biondetti P, Moggio M, Gaini SM, Stocchetti N, Priori A, D'Angelo MG, Turconi A, Bottinelli R, Cossu G, Rebulla P, Bresolin N. Autologous transplantation of muscle-derived CD133+ stem cells in Duchenne muscle patients. Cell Transplant. 16:563-77, 2007

Gammaitoni L, Lucchi S, Bruno S, Tesio M, Gunetti M, Pignochino Y, Migliardi G, Lazzari L, Aglietta M, Rebulla P, Piacibello Wanda. Serial transplantations in NOD/SCID mice of transduced human CD34+ cord blood cells. Efficient oncoretroviral gene transfer and ex vivo expansion under serum-free conditions. Stem Cells, 24:1201-12, 2006

Bossolasco P, Montemurro t, Cova L, Zangrossi S, Calzarossa C, Buiatiotis S, Soligo D, Bosari S, Silani V, Lambertenghi Deliliers G, Rebulla P, Lazzari L. Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential. Cell Research 16: 329-336, 2006

Ciulla MM, Giorgetti A, Silvestris I, Cortiana M, Montelatici E, Paliotti R, Annoni GA, Fiore AV, Giordano R, De Marco F, Magrini F, Rebulla P, Cortelezzi A, Lazzari L. Endothelial Colony Forming Capacity is Related to C-Reactive Protein Levels in Healthy Subjects. Current Neurovascular Research. 3:99-106, 2006

Ciulla MM, Giorgetti A, Lazzari L, Cortiana M, Silvestris I, Annoni G, De Asmundis C, Fiore AV, Montelatici E, Paliotti R, Magrini F, Rebulla P, Cortelezzi A. High-Altitude trekking in the Himalayas increases the activity of circulating endothelial cells. American Journal of Hematology. 79:76-8, 2005

Lazzari L, Montemurro T, Rebulla R. International forum: 3. Vox Sanguinis 89:173-4, 2005

Rebulla P, Giordano R. Cell therapy: an evolutionary development of transfusion medicine. Int J Cardiol. 95:S38-42, 2004

Giordano R, Lazzari L, Rebulla P. Clinical grade cell manipulation. Vox Sanguis 87:65-72, 2004

Ciulla MM, Ferrero S, Lazzari L, Pacchiana R, Paliotti R, Gianelli U, Busca G, Esposito A, Bosari S, Magrini F, Rebulla P. The translocation of mononuclear bone marrow cells after experimental myocardial cryoinjury is proportional to the infarcted area. Transfusion 44:239-44, 2004

Ciulla MM, Lazzari L, Pacchiana R, Esposito A, Ferrero S, Gianelli U, Paliotti R, Busca G, Giorgetti A, Magrini F, Rebulla P. Homing of peripherally injected bone marrow cells in rat after experimental myocardial injury. Haematologica 88:614-21, 2003

Giordano R, Lazzari L, Montemurro T, Lecchi L, Porretti L, Rebulla P. Clinical grade cell purification from thawed cord blood: an experience of "translation". Bone Marrow Transplantation 32:965-6, 2003

Rebulla P, Montemurro T, Giordano R, Lecchi L, Lazzari L. Plasticità delle cellule staminali: potenziali apllicazioni cliniche. Ann Ital Med Int, 17, 1-13, 2002

Engelfriet CP, Reesink HW, Wagner JE, Kogler G, Rocha V, Wernet P, Lecchi L, Lazzari L, Ratti I, Giovanelli S, Poli F, Rebulla P, Beguin Y, Baudoux E, Navarrete C, Armitage S, Laughlin MJ, McClelland WM. International forum. Use of umbilical cord blood progenitor cells as an alternative for bone marrow
transplantation. Vox Sanguinis 83:172-87, 2002

Lazzari L, Lucchi S, Porretti L, Montemurro T, Giordano R, Lopa R, Rebulla P, Sirchia G. Comparison of different serum-free media for ex vivo expansion of HPCs from cord blood using thrombopoietin, Flt-3 ligand, IL-6, and IL-11. Transfusion. 41:718-9, 2001

Lecchi L, Rebulla P, Ratti I, Magri M, Garcea F, Marangoni F, Bertele T, Giordano R, Sirchia G. Outcomes of a program to evaluate mother and baby 6 months after umbilical cord blood donation. Transfusion. May;41(5):606-10, 2001

Lazzari L, Lucchi S, Rebulla P, Porretti L, Puglisi G, Lecchi L, Sirchia G. Long-term expansion and maintenance of cord blood haematopoietic stem cells using thrombopoietin, Flt3-ligand, interleukin (IL)-6 and IL-11 in a serum-free and stroma-free culture system. British Journal of Haematology 112:397, 2001

Lazzari L, Lucchi S, Montemurro T, Porretti L, Lopa R, Rebulla P, Sirchia G. Evaluation of the effect of cryopreservation on ex vivo expansion of hematopoietic progenitors from cord blood. Bone Marrow Transplantation 28, 693-698, 2001

Marson P, Petris MG, Messina C, Cecchetto G, Giordano R, Zanesco L, De Silvestro G.
Peripheral blood stem cell collection in pediatric oncohematology. Experience with patients weighing less than 15 kg. Minerva Pediatr. 52:129-35, 2000

Lazzari L, Henschler R, Lecchi L, Rebulla P, Mertelsmann R, Sirchia G. Interleukin-6 and IL-11 act synergistically with thrombopoietin and stem cell factor to modulate ex vivo expansion of human CD41+ and CD61+ megakaryocytic cells. Haematologica 85: 25, 2000

Lecchi L, Ratti I, Lazzari L, Rebulla P, Sirchia G. Reasons for discard of umbilical cord blood units before cryopreservation. Transfusion 40: 122, 2000

Blundell MP, Demaison C, Brouns G, Kinnon C, Thrasher A, Lazzari L, Sirchia G. Quality of repopulation in nonobese diabetic severe combined immunodeficient mice engrafted with expanded cord blood CD34+ cells. Blood 4: 3269, 1999

Sirchia G, Rebulla P, Mozzi F, Lecchi L, Lazzari L, Ratti I. A quality system for placental blood banking. Bone Marrow Transplantation 21:S43-7, 1998

Bertolini F, Battaglia M, Soligo D, Corsini C, Curioni C, Lazzari L, Pedrazzoli P, Thalmeier K. "Stem cell candidates" purified by liquid culture in the presence of steel factor. IL-3 and 5FU are strictly stroma dependent and have a myeloid, lymphoid and megakaryocytic potential. Experimental Hematology 25: 350, 1997

Bertolini F, Corsini C, Lazzari L, Soligo D, De Monte L, Ward M, Bank a, Sirchia G. Gene transfer-mediated generation of drug-resistant hemopoiesis. Leukemia Lymphoma 21: 17; 1996

Lazzari L, Corsini C, Curioni C, Lecchi L, Scalamogna M, Rebulla P, Sirchia G. The Milan Cord Blood Bank and the Italian Network. Journal of Hematotherapy 5: 117, 1996

Bertolini F, Battaglia M, Corsini C, Lazzari L, Soligo D, Zibera C, Thalmeier K. Engineered stromal layers and continuous flow culture enhance multidrug resistance gene transfer in hematopoietic progenitors. Cancer Research 56: 2566, 1996

Bertolini F, Lazzari L, Lauri E, Corsini C, Castelli C, Gorini F, Sirchia G. A comparative study of different procedures for the collection and banking of umbilical cord blood. Journal of Hematotherapy, 4: 29, 1995

Bertolini F, Lazzari L, Lauri E, Corsini C, Sirchia G. Cord blood-derived hematopoietic progenitor cells retain their potential for ex-vivo expansion after cryopreservation. Bone Marrow Transplantation 15:159, 1995

Bertolini F, Soligo D, Lazzari L, Corsini C, Servida F, Sirchia G. The effect of interleukin 12 in ex-vivo expansion of human hematopoietic progenitors. British Journal of Haematology 90: 935, 1995

Bertolini F, De Monte L, Corsini C, Lazzari L, Lauri E, Soligo D, Malavasi F, Sirchia G. Retrovirus-mediated transfer of the multidrug resistance gene into human cord blood hematopoietic cells. British Journal of Haematology, 88: 318, 1994

Bertolini F, Lazzari L, Lauri E, Corsini C, Sirchia G. Cord blood plasma -mediated ex vivo expansion of hematopoietic progenitor cells. Bone Marrow Transplantation, 14: 347, 1994

Bertolini F, Lazzari L, Corsini C, Lauri E, Gorini F, Sirchia G. Cord blood banking for stem cell transplant. Int J Art Org, 16: 111-112, 1993